2. Signaling Pathways
  3. GPCR/G Protein
  4. Adenylate Cyclase

Adenylate Cyclase

Adenylyl cyclase

Adenylate Cyclase

Related Products

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Adenylyl cyclases (ACs) are enzymes that catalyze the production of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). Adenylyl cyclases integrate positive and negative signals that act through G protein-coupled cell-surface receptors with other extracellular stimuli to finely regulate levels of cAMP within the cell. Humans express nine isoforms of membranous ACs and a soluble AC.

Based on regulatory properties, transmembrane ACs are classified into four groups: Group I: Ca2+/calmodulin-stimulated AC1, AC3, AC8; Group II: Gβγ-stimulated and Ca2+-insensitive AC2, AC4, AC7; Group III: Gαi/Ca2+/PKA-inhibited AC5, AC6; Group IV: forskolin/Ca2+/Gβγ-insensitive AC9. The soluble AC, unlike the transmembrane ACs, is insensitive to hormones, G proteins and forskolin, a diterpene extracted from the root of the plant Coleus forskohlii that directly activates all isoforms of transmembrane ACs except AC9.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-103194R
    KH7 (Standard)
    		Inhibitor
    KH7 (Standard) is the analytical standard of KH7 (HY-103194). This product is intended for research and analytical applications. KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. KH7 is also a cAMP inhibitor.
    KH7 (Standard)
  • HY-134373A
    Bis-Cl-ANT-ATP tetrasodium
    		Inhibitor
    Bis-Cl-ANT-ATP (tetrasodium) is a fluorescent ATP derivative, which undergo spontaneous isomerization. Bis-Cl-ANT-ATP (tetrasodium) selectively inhibits B. pertussis Adenylyl Cyclase (AC) toxin CyaA over mammalian AC1, AC2, and AC5 (Kis = 16, 1,700, 2,400, and 1,600 nM, respectively). Bis-Br-ANT-ATP (tetrasodium) can be used in the study of whooping cough.
    Bis-Cl-ANT-ATP tetrasodium
  • HY-131776
    2-Chloro-ADP
    		Inhibitor
    2-Chloro-ADP (2-Chloroadenosine 5′-diphosphate) sis a Adenosine 5'-diphosphate (ADP; HY-W010918) derivative that induces human platelet aggregation and inhibits stimulated adenylate cyclase. 2-Chloro-ADP inhibits mortalin nucleotide-binding domain (NBD) with a Ki of 45.05 μM.
    2-Chloro-ADP
  • HY-P990425
    Anti-GPR73/PROKR1 Antibody
    		Inhibitor
    Anti-GPR73/PROKR1 Antibody is a CHO-expressed human antibody that targets GPR73/PROKR1. Anti-GPR73/PROKR1 Antibody features a huIgG4SP heavy chain and a huκ light chain, with an expected molecular weight (MW) of 150 kDa. The isotype control for Anti-GPR73/PROKR1 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-GPR73/PROKR1 Antibody
  • HY-103192R
    MDL12330A (Standard)
    		Inhibitor
    MDL12330A (Standard) is the analytical standard of MDL12330A (HY-103192). MDL12330A (RMI12330A) is an adenylyl cyclases inhibitor. MDL12330A can inhibit KV channels, increases insulin secretion and Ca2+ levels. MDL12330A accentuates contractions in uterine rings and inhibits cardiac functions. MDL12330A can be used for the research of endocrinology, metabolic and cardiovascular disease .
    MDL12330A (Standard)
  • HY-126055A
    Hadacidin sodium
    		Inhibitor
    Hadacidin sodium is a competitive inhibitor of adenylate synthase. Hadacidin sodium binds to the active site of adenylate synthase, competitively inhibiting L-aspartate binding. Hadacidin sodium can be used in drug design, to help develop new inhibitors or activators to regulate adenylate synthase activity, and to play a role in the study of related diseases.
    Hadacidin sodium
  • HY-161021
    AC2 selective-IN-1
    AC2 selective-IN-1 (compound 14) is a? potent (IC50=4.45 μM), non-toxic, and selective mAC2 inhibitor.
    AC2 selective-IN-1
  • HY-19100
    ADX-10061
    		Antagonist
    ADX-10061 (compound NNC 687) is a dopamine D1 receptor antagonist with the Ki values of 9.1 nM, 5.8 nM, > 10 000 nM and 355 nM for adenylyl cyclase, D1, D2 and 5-HT2 receptor, respectively. ADX-10061 can be used for study of schizophrenia.
    ADX-10061
  • HY-134372A
    Bis-Br-ANT-ATP tetrasodium
    		Inhibitor
    Bis-Br-ANT-ATP (tetrasodium) is a fluorescent derivative of adenosine-5’-triphosphate (ATP) (HY-B2176). Bis-Br-ANT-ATP (tetrasodium) selectively inhibits B. pertussis adenylyl cyclase toxin CyaA (Ki: 12.6 nM). Bis-Br-ANT-ATP (tetrasodium) can be used in Whooping cough research.
    Bis-Br-ANT-ATP tetrasodium
  • HY-B1124R
    Fipexide (Standard)
    		Inhibitor
    Fipexide (Standard) is the analytical standard of Fipexide. This product is intended for research and analytical applications. Fipexide, a parachloro-phenossiacetic acid derivative, is an orally active nootropic agent. Fipexide reduces striatal adenylate cyclase activity. Fipexide has positive effect on cognitive performance by dopaminergic neurotransmission. Fipexide is used for senile dementia research. Fipexide acts as a chemical inducer in callus formation, shoot regeneration and Agrobacterium infection.
    Fipexide (Standard)
  • HY-103185R
    CCPA (Standard)
    CCPA (2-Chloro-N6-cyclopentyladenosine (Standard)) is the analytical standard of CCPA (HY-103185). This product is intended for research and analytical applications. CCPA (2-Chloro-N6-cyclopentyladenosine) a highly selective A1 adenosine receptors agonist with a Ki of 0.4 nM. CCPA inhibits adenylate cyclase with an IC50 of 33 nM. CCPA exhibits anti-seizure and cardiacprotective activity. CCPA can be used for the research of seizure and myocardial infarction.
    CCPA (Standard)
  • HY-101279R
    ST034307 (Standard)
    		Inhibitor
    ST034307 (Standard) is the analytical standard of ST034307 (HY-101279). This product is intended for research and analytical applications. ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor, with IC50 of 2.3 μM.
    ST034307 (Standard)
  • HY-120547
    UCB-11056
    UCB-11056 is a modulator of cyclic AMP generation. UCB-11056 can rapidly increase cyclic AMP levels in the rat brain in vivo and potentiate stimulated cyclic AMP formation in vitro. UCB-11056 does not stimulate cAMP formation on its own. UCB-11056 is a potential nootropic drug.
    UCB-11056
  • HY-137748A
    3′-MANT-2′d-ATP tetrasodium
    3′-MANT-2′d-ATP (3′-MANT-2′deoxy-ATP ) tetrasodium is an inhibitor of edema factor. 3′-MANT-2′d-ATP tetrasodium inhibits the catalytic activity of EF3.
    3′-MANT-2′d-ATP tetrasodium
  • HY-173215
    3-Dimethylaminopropyl deacetylforskolin
    		Activator
    3-Dimethylaminopropyl deacetylforskolin is a dehydro derivative of adenylate cyclase activator Forskolin (HY-15371) and may cause cross-immunoreactivity with anti-Forskolin antibodies.
    3-Dimethylaminopropyl deacetylforskolin
  • HY-155404
    Adenylyl cyclase-IN-1
    		Inhibitor
    Adenylyl cyclase-IN-1 is an adenylyl cyclase inhibitor with potential use in ocular hypotonia research.
    Adenylyl cyclase-IN-1
  • HY-103195R
    NKY80 (Standard)
    		Inhibitor
    NKY80 (Standard) is the analytical standard of NKY80 (HY-103195). This product is intended for research and analytical applications. NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC50s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues.
    NKY80 (Standard)
Cat. No. Product Name / Synonyms Application Reactivity